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Identification of Brucella RS15060 as a novel type IV secretion system effector associated with bacterial virulence

18 Dec 2024

Abstract excerpt

Brucella is an intracellular parasitic pathogen that causes the worldwide zoonotic disease brucellosis. The type IV secretion system (T4SS) is utilized to secrete various effectors to help Brucella form Brucella-containing vacuoles within the cell and accomplish intracellular trafficking and replication. Brucella has fewer recognized effector proteins than other intracellular parasites in the Proteobacteria,...

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PMID: 39696601
DOI: 10.1186/s13567-024-01417-4

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