Article
Neuronal Menin Overexpression Rescues Learning and Memory Phenotype in CA1-Specific α7 nAChRs KD Mice.
Cells - 24 Nov 2021
Batool Shadab, Akhter Basma, Zaidi Jawwad, Visser Frank, Petrie Gavin, Hill Matthew, Syed Naweed I
Abstract excerpt
The perturbation of nicotinic cholinergic receptors is thought to underlie many neurodegenerative and neuropsychiatric disorders, such as Alzheimer's and schizophrenia. We previously identified that the tumor suppressor gene, MEN1, regulates both the expression and synaptic targeting of α7 nAChRs in the mouse hippocampal neurons in vitro. Here we sought to determine whether the α7 nAChRs gene expression...
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