Article
Drivers and sites of diversity in the DNA adenine methylomes of 93 Mycobacterium tuberculosis complex clinical isolates.
eLife - 27 Oct 2020
Modlin Samuel J, Conkle-Gutierrez Derek, Kim Calvin, Mitchell Scott N, Morrissey Christopher, Weinrick Brian C, Jacobs William R, Ramirez-Busby Sarah M, Hoffner Sven E, Valafar Faramarz
Abstract excerpt
This study assembles DNA adenine methylomes for 93 Mycobacterium tuberculosis complex (MTBC) isolates from seven lineages paired with fully-annotated, finished, de novo assembled genomes. Integrative analysis yielded four key results. First, methyltransferase allele-methylome mapping corrected methyltransferase variant effects previously obscured by reference-based variant calling. Second, heterogeneity analysis...
Topics
- Adenine
- DNA Methylation
- Epigenome
- Genetic Variation
- Mutation
- Mycobacterium tuberculosis