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Dietary fiber and probiotics influence the gut microbiome and melanoma immunotherapy response

23 Dec 2021

Abstract excerpt

Gut bacteria modulate the response to immune checkpoint blockade (ICB) treatment in cancer, but the effect of diet and supplements on this interaction is not well studied. We assessed fecal microbiota profiles, dietary habits, and commercially available probiotic supplement use in melanoma patients and performed parallel preclinical studies. Higher dietary fiber was associated with significantly improved...

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PMID: 34941392
DOI: 10.1126/science.aaz7015

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