Article

Gut microbiota signatures are associated with toxicity to combined CTLA-4 and PD-1 blockade

2020-12-07

Abstract excerpt

<title>Abstract</title> <p>Treatment with combined immune checkpoint blockade (CICB) targeting CTLA-4 and PD-1 is associated with clinical benefit across tumor types, but a high rate of immune-related adverse events (irAE). Insights into biomarkers and mechanisms of response and toxicity to CICB are needed. To address this, we profiled the blood, tumor and gut microbiome of 77 advanced melanoma patients treated w...

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Literature Corpus work: 0f5c917d-cf79-58bc-81be-d612088b87ce
DOI: 10.21203/rs.3.rs-119925/v1

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