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Extent, impact, and mitigation of batch effects in tumor biomarker studies using tissue microarrays

23 Dec 2021

Abstract excerpt

Tissue microarrays (TMAs) have been used in thousands of cancer biomarker studies. To what extent batch effects, measurement error in biomarker levels between slides, affects TMA-based studies has not been assessed systematically. We evaluated 20 protein biomarkers on 14 TMAs with prospectively collected tumor tissue from 1448 primary prostate cancers. In half of the biomarkers, more than 10% of biomarker...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 34939926
DOI: 10.7554/elife.71265

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