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Article

Study Design Considerations for Cancer Biomarker Discoveries

26 Aug 2018

Abstract excerpt

Background: Biomarker discovery studies have generated an array of omic data, however few novel biomarkers have reached clinical use. Guidelines for rigorous study designs are needed. Content: Biases frequently occur in sample selection, outcome ascertainment, or unblinded sample handling and assaying process. The principles of a prospective-specimen collection and retrospective-blinded-evaluation (PRoBE) design...

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PMID: 30828695
DOI: 10.1373/jalm.2017.025809

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