Article
Circadian Clock Gene Polymorphisms and Sleep-Onset Problems in a Population-Based Cohort Study: The Yamagata Study.
The Tohoku journal of experimental medicine - 1 Dec 2021
Sakurada Kaori, Konta Tsuneo, Takahashi Sanae, Murakami Narumi, Sato Hidenori, Murakami Ryoko, Watanabe Masafumi, Ishizawa Kenichi, Ueno Yoshiyuki, Yamashita Hidetoshi, Kayama Takamasa
Abstract excerpt
A number of genome-wide association studies have investigated sleep phenotypes and disorders in humans. However, the contribution of genetic variation to sleep problems in Japanese populations has remained unclear. Sleep-onset problems are the most common symptom of insomnia. Here, we examined the relationship between single nucleotide polymorphisms (SNPs) of BMAL1 (ARNTL1), CLOCK, CRY1, CRY2, and PER2, which are...
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