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Article

Peripheral Clock System Abnormalities in Patients With Parkinson’s Disease

1 Oct 2021

Abstract excerpt

Objective: To evaluate the altered expression of peripheral clock genes, circulating melatonin levels, and their correlations with sleep-wake phenotypes including probable rapid eye movement sleep behavior disorder (pRBD) symptoms in a relatively large population of Parkinson’s disease (PD) patients. Methods: We determined the expression profiles of five principal clock genes, BMAL1, CLOCK, CRY1, PER1, and PER2,...

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Share to Circadian rhythm and melatonin
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PMID: 34658839
DOI: 10.3389/fnagi.2021.736026

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