Genomic profiling of the UFMylation family genes identifies UFSP2 as a potential tumour suppressor in colon cancer

Abstract excerpt

The ubiquitin and ubiquitin-like protein modifications contribute to functional changes of substrate proteins and thus regulate a range of biological processes including cancer.1 Ubiquitin-fold modifier 1 (UFM1) is a newly identified ubiquitin-like modification with essential biological functions.2, 3 Like ubiquitination, UFM1 modification (UFMylation) is catalyzed by the dynamic E1–E2–E3 enzymatic reaction....

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