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Article

F‐box protein <scp>FBXL</scp>2 inhibits gastric cancer proliferation by ubiquitin‐mediated degradation of forkhead box M1

21 Jan 2016

Abstract excerpt

F-box/LRR-repeat protein 2 (FBXL2), a component of Skp-Cullin-F box (SCF) ubiquitin E3 ligase, has been shown to inhibit tumorigenesis by targeting and ubiquitinating several oncoproteins. However, its role in gastric cancer remains poorly understood. Here, by tandem mass spectrometry, we show that FBXL2 interacts with forkhead box M1 (FoxM1) transcription factor. As a result, FBXL2 promotes ubiquitination and...

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PMID: 26790640
DOI: 10.1002/1873-3468.12071

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