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Article

Periconceptional 1,3-butanediol supplementation suppresses the superimposed preeclampsia-like phenotype in the Dahl salt-sensitive rat.

American journal of physiology. Heart and circulatory physiology - 1 Feb 2022

Ishimwe Jeanne A, Baker Melanie B, Garrett Michael R, Sasser Jennifer M

Abstract excerpt

Preeclampsia is a hypertensive pregnancy disorder with no treatment beyond management of symptoms and delivery of the fetus and placenta. Chronic hypertension increases the risk of developing superimposed preeclampsia. Previous reports showed that 1,3-butanediol attenuates hypertension in rodents; however, the therapeutic potential of 1,3-butanediol for the prevention of preeclampsia has not been investigated....

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Source

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Identifiers

PMID: 34919457
DOI: 10.1152/ajpheart.00060.2021
PMCID: PMC8782659

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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