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Article

Construction of the experimental rat model of gestational diabetes

15 Sept 2022

Abstract excerpt

OBJECTIVE: Numerous methods for modeling gestational diabetes mellitus (GDM) in rats exist. However, their repeatability and stability are unclear. This study aimed to compare the effects of high-fat and high-sugar (HFHS) diet, HFHS diet combined with streptozotocin (STZ) administration, and HFHS diet combined with movement restriction (MR) modeling methods on rat models to confirm the best method for...

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PMID: 36107823
DOI: 10.1371/journal.pone.0273703

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