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Article

Population genetic analysis of the N-acylsphingosine amidohydrolase gene associated with mental activity in humans.

Genetics - 1 Mar 2008

Kim Hie Lim, Satta Yoko

Abstract excerpt

To understand the evolution of human mental activity, we performed population genetic analyses of nucleotide sequences ( approximately 11 kb) from a worldwide sample of 60 chromosomes of the N-acylsphingosine amidohydrolase (ASAH1) gene. ASAH1 hydrolyzes ceramides and regulates neuronal development, and its deficiency often results in mental retardation. In the region ( approximately 4.4 kb) encompassing exons 3...

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Identifiers

PMID: 18245333
DOI: 10.1534/genetics.107.083691
PMCID: PMC2278054

Genes

ASAH1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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