Candidate gene analysis and exome sequencing confirm LBX1 as a susceptibility gene for idiopathic scoliosis.

doi:10.1016/j.spinee.2015.05.013

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Article

Candidate gene analysis and exome sequencing confirm LBX1 as a susceptibility gene for idiopathic scoliosis.

The spine journal : official journal of the North American Spine Society - 1 Oct 2015

Grauers Anna, Wang Jingwen, Einarsdottir Elisabet, Simony Ane, Danielsson Aina, Åkesson Kristina, Ohlin Acke, Halldin Klas, Grabowski Pawel, Tenne Max, Laivuori Hannele, Dahlman Ingrid, Andersen Mikkel, Christensen Steen Bach, Karlsson Magnus K, Jiao Hong, Kere Juha, Gerdhem Paul

Abstract excerpt

BACKGROUND CONTEXT: Idiopathic scoliosis is a spinal deformity affecting approximately 3% of otherwise healthy children or adolescents. The etiology is still largely unknown but has an important genetic component. Genome-wide association studies have identified a number of common genetic variants that are significantly associated with idiopathic scoliosis in Asian and Caucasian populations, rs11190870 close to...

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PMID: 25987191
DOI: 10.1016/j.spinee.2015.05.013

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LBX1

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Related research

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Candidate gene analysis and exome sequencing confirm LBX1 as a susceptibility gene for idiopathic scoliosis.PMID 25987191Read ↗

A genome-wide association study identifies common variants near LBX1 associated with adolescent idiopathic scoliosis.Semantic proximity Read ↗

A Replication Study for Association of LBX1 Locus With Adolescent Idiopathic Scoliosis in French-Canadian Population.Semantic proximity Read ↗

A meta-analysis identifies adolescent idiopathic scoliosis association with LBX1 locus in multiple ethnic groups.Semantic proximity Read ↗

Haplotypes at LBX1 have distinct inheritance patterns with opposite effects in adolescent idiopathic scoliosis.Semantic proximity Read ↗

Whole genome sequencing in adolescent idiopathic scoliosis cohort implicates multiple biological pathwaysSemantic proximity Read ↗

Association between genetic polymorphisms and risk of adolescent idiopathic scoliosis in case-control studies: a systematic review.Semantic proximity Read ↗

Association between common variants near LBX1 and adolescent idiopathic scoliosis replicated in the Chinese Han population.Semantic proximity Read ↗

Whole Genome Sequencing in Adolescent Idiopathic Scoliosis Cohort Indicates Polygenic Disease Involving Multiple Biological PathwaysSemantic proximity Read ↗

Associations of LBX1 gene and adolescent idiopathic scoliosis susceptibility: a meta-analysis based on 34,626 subjects.Semantic proximity Read ↗

Identification of novel FBN1 variations implicated in congenital scoliosis.Semantic proximity Read ↗

Single Nucleotide Polymorphisms and Adolescent Idiopathic Scoliosis: A Systematic Review and Meta-Analysis of the Literature.Semantic proximity Read ↗

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