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Article

TAZ-induced Cybb contributes to liver tumor formation in non-alcoholic steatohepatitis

11 Dec 2021

Abstract excerpt

BACKGROUND & AIMS: Non-alcoholic steatohepatitis (NASH) is a leading cause of hepatocellular carcinoma (HCC), but mechanisms linking NASH to eventual tumor formation remain poorly understood. Herein, we investigate the role of TAZ/WWTR1, which is induced in hepatocytes in NASH, in the progression of NASH to HCC. METHODS: The roles of hepatocyte TAZ and its downstream targets were investigated in diet-induced and...

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PMID: 34902531
DOI: 10.1016/j.jhep.2021.11.031

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