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Article

Extent, pattern, and prognostic value of MGMT promotor methylation: does it differ between glioblastoma and IDH-wildtype/TERT-mutated astrocytoma?

Journal of neuro-oncology - 1 Jan 2022

Teske Nico, Karschnia Philipp, Weller Jonathan, Siller Sebastian, Dorostkar Mario M, Herms Jochen, von Baumgarten Louisa, Tonn Joerg Christian, Thon Niklas

Abstract excerpt

INTRODUCTION: The cIMPACT-NOW update 6 first introduced glioblastoma diagnosis based on the combination of IDH-wildtype (IDHwt) status and TERT promotor mutation (pTERTmut). In glioblastoma as defined by histopathology according to the WHO 2016 classification, MGMT promotor status is associated with outcome. Whether this is also true in glioblastoma defined by molecular markers is yet unclear. METHODS: We...

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Identifiers

PMID: 34902093
DOI: 10.1007/s11060-021-03912-6
PMCID: PMC8816375

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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