Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

AAMP promotes colorectal cancer metastasis by suppressing SMURF2-mediated ubiquitination and degradation of RhoA

11 Nov 2021

Abstract excerpt

Metastasis is considered the leading cause of cancer death due to the limited possibilities to therapeutically target this process. How the ubiquitination machinery contributes to metastasis remains underexplored. Angio-associated migratory cell protein (AAMP), a ubiquitously expressed protein involved in cell migration, has been reported to play oncogenic roles in breast and non-small cell lung cancer (NSCLC)....

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer, Hypoxia, and Metabolism
Share to Cancer-related Molecular Pathways
Share to Ubiquitin and proteasome pathways

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 34901393
DOI: 10.1016/j.omto.2021.11.007

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

AAMP promotes colorectal cancer metastasis by suppressing SMURF2-mediated ubiquitination and degradation of RhoAPMID 34901393Read ↗

Smad Ubiquitination Regulatory Factor 2 Promotes Metastasis of Breast Cancer Cells by Enhancing Migration and InvasivenessSemantic proximity Read ↗

MYO10 contributes to the malignant phenotypes of colorectal cancer via RACK1 by activating integrin/Src/FAK signaling.Semantic proximity Read ↗

Colorectal cancer cell intrinsic fibroblast activation protein alpha binds to Enolase1 and activates NF-κB pathway to promote metastasisSemantic proximity Read ↗

RASSF1A Directly Antagonizes RhoA Activity through the Assembly of a Smurf1-Mediated Destruction Complex to Suppress Tumorigenesis.Semantic proximity Read ↗

IRX5 promotes colorectal cancer metastasis by negatively regulating the core components of the RHOA pathwaySemantic proximity Read ↗

A novel FOXM1 isoform, FOXM1D, promotes epithelial–mesenchymal transition and metastasis through ROCKs activation in colorectal cancerSemantic proximity Read ↗

Transcriptional activation of FN1 and IL11 by HMGA2 promotes the malignant behavior of colorectal cancerSemantic proximity Read ↗

A Smurf1 tale: function and regulation of an ubiquitin ligase in multiple cellular networks.Semantic proximity Read ↗

Targeting Smurf1 to block PDK1-Akt signaling in KRAS-mutated colorectal cancer.Semantic proximity Read ↗

FBXO28 suppresses liver cancer invasion and metastasis by promoting PKA-dependent SNAI2 degradationSemantic proximity Read ↗

The deubiquitinating enzyme PSMD14 facilitates tumor growth and chemoresistance through stabilizing the ALK2 receptor in the initiation of BMP6 signaling pathwaySemantic proximity Read ↗

The role of HMGA2 in activating the IGFBP2 expression to promote angiogenesis and LUAD metastasis via the PI3K/AKT/VEGFA signaling pathwaySemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.