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Article

IRX5 promotes colorectal cancer metastasis by negatively regulating the core components of the RHOA pathway

20 Aug 2019

Abstract excerpt

Colorectal cancer (CRC) is one of the most common malignant tumors worldwide. As tumor metastasis is the leading cause of death in patients with CRC, it is important to elucidate the molecular mechanisms that drive CRC metastasis. Studies have shown a close relationship between Iroquois homeobox (IRX) family genes and multiple cancers, while the mechanism by which IRX5 promotes CRC metastasis is unclear....

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PMID: 31432570
DOI: 10.1002/mc.23098

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