Colorectal cancer cell intrinsic fibroblast activation protein alpha binds to Enolase1 and activates NF-κB pathway to promote metastasis

Abstract excerpt

Fibroblast activation protein alpha (FAP) is a marker of cancer-associated fibroblast, which is also expressed in cancer epithelial cells. However, the role of FAP in colorectal cancer (CRC) cells remains to be elucidated. Here we investigate the expression pattern of FAP in CRC tissues and cells to prove that FAP is upregulated in CRC cells. Loss- of and gain-of-function assays identified FAP promotes migration...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Pancreatic and Hepatic Oncology Research
• Share to Peptidase Inhibition and Analysis
• Share to Ubiquitin and proteasome pathways