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Article

Programmed Cell Death 1 and Hepatocellular Carcinoma: An Epochal Story.

Journal of gastrointestinal cancer - 1 Dec 2021

Demirtas Coskun Ozer, Gunduz Feyza

Abstract excerpt

In recent years, immune-based therapies have emerged as novel pillars for hepatocellular carcinoma (HCC). The rationale of immune-checkpoint inhibitors (ICIs) trial in HCC originated from the fact that the tumor cells and the infiltrating stromal and immune cells promote an immunosuppressive tumor microenvironment, including the up-regulation of immune checkpoint molecules on their surface. Antibody-based...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 34897577
DOI: 10.1007/s12029-021-00758-z

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