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Article

Inhibition of prolyl oligopeptidase: A promising pathway to prevent the progression of age-related macular degeneration.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie - 1 Feb 2022

Hellinen Laura, Koskela Ali, Vattulainen Elina, Liukkonen Mikko, Wegler Christine, Treyer Andrea, Handin Niklas, Svensson Richard, Myöhänen Timo, Poso Antti, Kaarniranta Kai, Artursson Per, Urtti Arto

Abstract excerpt

Dry age-related macular degeneration (AMD) is a currently untreatable vision threatening disease. Impaired proteasomal clearance and autophagy in the retinal pigment epithelium (RPE) and subsequent photoreceptor damage are connected with dry AMD, but detailed pathophysiology is still unclear. In this paper, we discover inhibition of cytosolic protease, prolyl oligopeptidase (PREP), as a potential pathway to treat...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 34891119
DOI: 10.1016/j.biopha.2021.112501

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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