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Article

Protective effect of HLA-DQB1 alleles against alloimmunization in patients with sickle cell disease.

Human immunology - 1 Jan 2016

Tatari-Calderone Zohreh, Gordish-Dressman Heather, Fasano Ross, Riggs Michael, Fortier Catherine, Campbell Andrew D, Charron Dominique, Gordeuk Victor R, Luban Naomi L C, Vukmanovic Stanislav, Tamouza Ryad

Abstract excerpt

BACKGROUND: Alloimmunization or the development of alloantibodies to Red Blood Cell (RBC) antigens is considered one of the major complications after RBC transfusions in patients with sickle cell disease (SCD) and can lead to both acute and delayed hemolytic reactions. It has been suggested that polymorphisms in HLA genes, may play a role in alloimmunization. We conducted a retrospective study analyzing the...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 26476208
DOI: 10.1016/j.humimm.2015.10.010
PMCID: PMC4747802

Genes

SCD

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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