Article
p28, an anionic cell-penetrating peptide, increases the activity of wild type and mutated p53 without altering its conformation.
Molecular pharmaceutics - 3 Sept 2013
Yamada Tohru, Das Gupta Tapas K, Beattie Craig W
Abstract excerpt
p28, a cell penetrating peptide, binds to the DNA binding domain (DBD) of p53, inducing a post-translational increase in intracellular levels of wild type and mutant p53 activating pathways that inhibit cancer cell proliferation at G2/M. Cancer cells respond to p28 with an increase in p53 activity, except when mutations either alter DNA contact or completely unfold the DBD. The increase in p53 activity is...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.