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Article

Synthesis and biological evaluation of novel 5,6-dihydrobenzo[h]quinazoline derivatives as FLT3 inhibitors.

Chemical biology & drug design - 1 Apr 2022

Ding Lei, Zhang Qing, Zhao Kuantao, Jiao Xiaoyu, Zhou Ying, Fan Weizheng, Tang Chunlei

Abstract excerpt

Fms-like tyrosine kinase 3 (FLT3) is widely expressed and often mutated in acute myeloid leukemia (AML), which makes it an important target for the treatment of AML. The structure-based synthesis and biological evaluation of 5,6-dihydrobenzo[h]quinazoline derivatives as FLT3 inhibitors have been studied in this paper. III-1a, III-1c, III-2a, III-2c, and III-4a displayed comparable inhibitory potency against...

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PMID: 34877799
DOI: 10.1111/cbdd.13992

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