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EfgA is a conserved formaldehyde sensor that leads to bacterial growth arrest in response to elevated formaldehyde

26 May 2021

Abstract excerpt

Normal cellular processes give rise to toxic metabolites that cells must mitigate. Formaldehyde is a universal stressor and potent metabolic toxin that is generated in organisms from bacteria to humans. Methylotrophic bacteria such as Methylorubrum extorquens face an acute challenge due to their production of formaldehyde as an obligate central intermediate of single-carbon metabolism. Mechanisms to sense and...

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PMID: 34038406
DOI: 10.1371/journal.pbio.3001208

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