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Article

P-gp expression inhibition mediates placental glucocorticoid barrier opening and fetal weight loss

1 Dec 2021

Abstract excerpt

BACKGROUND: Prenatal adverse environments can cause fetal intrauterine growth retardation (IUGR) and higher susceptibility to multiple diseases after birth, related to multi-organ development programming changes mediated by intrauterine overexposure to maternal glucocorticoids. As a glucocorticoid barrier, P-glycoprotein (P-gp) is highly expressed in placental syncytiotrophoblasts; however, the effect of P-gp on...

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PMID: 34876109
DOI: 10.1186/s12916-021-02173-4

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