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Article

An update on expression and function of P-gp/ABCB1 and BCRP/ABCG2 in the placenta and fetus

16 Jul 2018

Abstract excerpt

INTRODUCTION: P-glycoprotein (P-gp)/ABCB1 and breast cancer resistance protein (BCRP)/ABCG2 are highly expressed in the placenta and fetus throughout gestation and can modulate exposure and toxicity of drugs and xenobiotics to the vulnerable fetus during the sensitive times of growth and development. We aim to provide an update on current knowledge on placental and fetal expressions of the two transporters in...

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PMID: 30010462
DOI: 10.1080/17425255.2018.1499726

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