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Article

BCRP/ABCG2 in the Placenta: Expression, Function and Regulation

17 Jan 2008

Abstract excerpt

Knowledge concerning transport of maternally administered drugs across the placental barrier is essential for determining potential toxicity of drugs to the fetus and the value of drug therapy during pregnancy. An important determinant for fetal drug exposure is the expression of efflux transporters in the placenta. Among human tissues, the ATP-binding cassette efflux transporter BCRP (gene symbol ABCG2) is most...

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PMID: 18202831
DOI: 10.1007/s11095-008-9537-z

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