Article
BRAF somatic mutation contributes to intrinsic epileptogenicity in pediatric brain tumors.
Nature medicine - 1 Nov 2018
Koh Hyun Yong, Kim Se Hoon, Jang Jaeson, Kim Hyungguk, Han Sungwook, Lim Jae Seok, Son Geurim, Choi Junjeong, Park Byung Ouk, Heo Won Do, Han Jinju, Lee Hyunjoo Jenny, Lee Daeyoup, Kang Hoon-Chul, Shong Minho, Paik Se-Bum, Kim Dong Seok, Lee Jeong Ho
Abstract excerpt
Pediatric brain tumors are highly associated with epileptic seizures1. However, their epileptogenic mechanisms remain unclear. Here, we show that the oncogenic BRAF somatic mutation p.Val600Glu (V600E) in developing neurons underlies intrinsic epileptogenicity in ganglioglioma, one of the leading causes of intractable epilepsy2. To do so, we developed a mouse model harboring the BRAFV600E somatic mutation during...
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