Article
Structural basis for continued antibody evasion by the SARS-CoV-2 receptor binding domain.
Science (New York, N.Y.) - 21 Jan 2022
Nabel Katherine G, Clark Sarah A, Shankar Sundaresh, Pan Junhua, Clark Lars E, Yang Pan, Coscia Adrian, McKay Lindsay G A, Varnum Haley H, Brusic Vesna, Tolan Nicole V, Zhou Guohai, Desjardins Michaël, Turbett Sarah E, Kanjilal Sanjat, Sherman Amy C, Dighe Anand, LaRocque Regina C, Ryan Edward T, Tylek Casey, Cohen-Solal Joel F, Darcy Anhdao T, Tavella Davide, Clabbers Anca, Fan Yao, Griffiths Anthony, Correia Ivan R, Seagal Jane, Baden Lindsey R, Charles Richelle C, Abraham Jonathan
Abstract excerpt
Many studies have examined the impact of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants on neutralizing antibody activity after they have become dominant strains. Here, we evaluate the consequences of further viral evolution. We demonstrate mechanisms through which the SARS-CoV-2 receptor binding domain (RBD) can tolerate large numbers of simultaneous antibody escape mutations and show that...
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