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Quantification of cell-free DNA for the analysis of CD19-CAR-T cells during lymphoma treatment

28 Oct 2021

Abstract excerpt

Chimeric antigen receptor (CAR)-T cells are increasingly used for the treatment of hematologic malignancies. Treatment success relies highly upon sufficient expansion of CAR-T effector cells. Accordingly, longitudinal quantification of CAR-T cells during therapy is clinically important. Techniques to quantify CAR-T cells in patient blood samples are based on flow cytometry and PCR. However, cellular kinetics of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 34853800
DOI: 10.1016/j.omtm.2021.10.009

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