Article
A novel loop-mediated isothermal amplification-based genotyping method and its application for identifying proprotein convertase subtilisin/kexin type 9 variants in familial hypercholesterolemia.
Biochimica et biophysica acta. General subjects - 1 Feb 2022
Hamasaki Masato, Hosaka Norimitsu, Freeman Lita A, Sato Masaki, Hara Kazuo, Remaley Alan T, Kotani Kazuhiko
Abstract excerpt
BACKGROUND: Proprotein convertase subtilisin/kexin type 9 (PCSK9) plays a key role in regulating low-density lipoprotein levels in plasma. While PCSK9 variants are causatively associated with familial hypercholesterolemia (FH), additional genotyping methods for FH targeting PCSK9 variants are required in a clinical setting. Loop-mediated isothermal amplification (LAMP) is a unique amplification method that...
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