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Addressing inter individual variability in CSF levels of brain derived proteins across neurodegenerative diseases

3 Jan 2025

Abstract excerpt

Accurate diagnosis and monitoring of neurodegenerative diseases require reliable biomarkers. Cerebrospinal fluid (CSF) proteins are promising candidates for reflecting brain pathology; however, their diagnostic utility may be compromised by natural variability between individuals, weakening their association with disease. Here, we measured the levels of 69 pre-selected proteins in cerebrospinal fluid using...

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PMID: 39753643
DOI: 10.1038/s41598-024-83281-y

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