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Rescue of Senecavirus A to uncover mutation profiles of its progenies during 80 serial passages in vitro.

Veterinary microbiology - 1 Feb 2021

Liu Fuxiao, Huang Yilan, Wang Qianqian, Li Juan, Shan Hu

Abstract excerpt

Senecavirus A (SVA), also known as Seneca Valley virus, belongs to the genus Senecavirus in the family Picornaviridae. In this study, a China SVA isolate (CH-LX-01-2016) was rescued from its cDNA clone, and then identified by RT-PCR, indirect immunofluorescence assay and mass spectrometry. The rescued SVA could separately induce typical plaque formations and cytopathic effects in cell monolayers. In order to...

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PMID: 33450657
DOI: 10.1016/j.vetmic.2020.108969

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