A large variation in the rates of synonymous substitution for RNA viruses and its relationship to a diversity of viral infection and transmission modes.

Abstract excerpt

RNA viruses successfully adapt to various environments by repeatedly producing new mutants, often through generating a number of nucleotide substitutions. To estimate the degree of variation in mutation rates of RNA viruses and to understand the source of such variation, we studied the synonymous substitution rate because synonymous substitution is exempt from functional constraints at the protein level, and its...

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