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A CRISPR Activation Screen Identifies an Atypical Rho GTPase That Enhances Zika Viral Entry

20 Oct 2021

Abstract excerpt

Zika virus (ZIKV) is a re-emerging flavivirus that has caused large-scale epidemics. Infection during pregnancy can lead to neurologic developmental abnormalities in children. There is no approved vaccine or therapy for ZIKV. To uncover cellular pathways required for ZIKV that can be therapeutically targeted, we transcriptionally upregulated all known human coding genes with an engineered CRISPR–Cas9 activation...

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PMID: 34834920
DOI: 10.3390/v13112113

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