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Article

Hepatocellular carcinoma cell line-microenvironment induced cancer-associated phenotype, genotype and functionality in mesenchymal stem cells.

Life sciences - 1 Jan 2022

Salah Radwa Ayman, Nasr Mohamed A, El-Derby Azza M, Abd Elkodous M, Mohamed Rania Hassan, El-Ekiaby Nada, Osama Aya, Elshenawy Shimaa E, Hamad Merna Hatem Mohamed, Magdeldin Sameh, Gabr Mahmoud M, Abdelaziz Ahmed I, El-Badri Nagwa S

Abstract excerpt

Mesenchymal stromal cells (MSCs) have shown promise in liver cancer treatment. However, when MSCs are recruited to hepatic site of injury, they acquire cancerous promoting phenotype. AIMS: To assess the influence of Hepatocellular carcinoma (HCC) microenvironment on human adipose MSCs (hA-MSCs) and predict hA-MSCs intracellular miRNAs role. MATERIALS AND METHODS: After indirect co-culturing with Huh-7 cells,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 34826437
DOI: 10.1016/j.lfs.2021.120168

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