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Article

Human ovarian carcinoma–associated mesenchymal stem cells regulate cancer stem cells and tumorigenesis via altered BMP production.

The Journal of clinical investigation - 1 Aug 2011

McLean Karen, Gong Yusong, Choi Yunjung, Deng Ning, Yang Kun, Bai Shoumei, Cabrera Lourdes, Keller Evan, McCauley Laurie, Cho Kathleen R, Buckanovich Ronald J

Abstract excerpt

Accumulating evidence suggests that mesenchymal stem cells (MSCs) are recruited to the tumor microenvironment; however, controversy exists regarding their role in solid tumors. In this study, we identified and confirmed the presence of carcinoma-associated MSCs (CA-MSCs) in the majority of human...

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Topics

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Share to Bone Morphogenetic Proteins
Share to Cell Differentiation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Gene Expression Regulation, Neoplastic

Share to Mesenchymal Stem Cells

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Share to Ovarian Neoplasms

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Source

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Identifiers

PMID: 21737876
DOI: 10.1172/JCI45273
PMCID: PMC3148732

Genes

BMP2
BMP4
BMP6
MSC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-21737876-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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