Article
Reversibility of hAT-MSCs phenotypic and metabolic changes after exposure to and withdrawal from HCC-conditioned medium through regulation of the ROS/MAPK/HIF-1α signaling pathway.
Stem cell research & therapy - 27 Nov 2020
Wang Chenyang, Hu Jie, Chen Zheng, Wang Yifan, Lu Sinan, Zhang Yuan, Li Yufeng, Xiang Yucheng, Ji Yutian, Zeng Cheng, Ding Yuan, Wang Weilin
Abstract excerpt
BACKGROUND: Mesenchymal stem cells (MSCs) play an important role in tumor progression; concomitantly, MSCs also undergo profound changes in the tumor microenvironment (TME). These changes can directly impact the application and efficacy of MSC-based anti-tumor therapy. However, few studies have focused on the regulation of MSC fate in TME, which will limit the progress of MSC-based anti-tumor therapy. Herein, we...
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