Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Transcriptional profiling of mESC-derived tendon and fibrocartilage cell fate switch

9 Jul 2021

Abstract excerpt

The transcriptional regulators underlying induction and differentiation of dense connective tissues such as tendon and related fibrocartilaginous tissues (meniscus and annulus fibrosus) remain largely unknown. Using an iterative approach informed by developmental cues and single cell RNA sequencing (scRNA-seq), we establish directed differentiation models to generate tendon and fibrocartilage cells from mouse...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Knee injuries and reconstruction techniques
Share to Tendon Structure and Treatment

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 34244516
DOI: 10.1038/s41467-021-24535-5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Transcriptional profiling of mESC-derived tendon and fibrocartilage cell fate switchPMID 34244516Read ↗

Defining the spatial-molecular map of fibrotic tendon healing and the drivers of Scleraxis-lineage cell fate and functionSemantic proximity Read ↗

Single Cell Transcriptomics-Informed Induced Pluripotent Stem Cells Differentiation to Tenogenic LineageSemantic proximity Read ↗

Single-cell Transcriptomics Identify Extensive Heterogeneity in the Cellular Composition of Mouse Achilles TendonsSemantic proximity Read ↗

Cellular and molecular landscapes of human tendons across the lifespan revealed by spatial and single-cell transcriptomicsSemantic proximity Read ↗

Epitenon-derived cells comprise a distinct progenitor population that contributes to both fibrosis and regeneration following acute flexor tendon injury in a spatially-dependent mannerSemantic proximity Read ↗

Single-cell transcriptomic analysis identifies extensive heterogeneity in the cellular composition of mouse Achilles tendonsSemantic proximity Read ↗

Molecular dissection of tendon development and healing: Insights into tenogenic phenotypes and functions.Semantic proximity Read ↗

Embryonic mechanical and soluble cues regulate tendon progenitor cell gene expression as a function of developmental stage and anatomical origin.Semantic proximity Read ↗

Single-cell and spatial transcriptomics reveal changes in cell heterogeneity during progression of human tendinopathySemantic proximity Read ↗

Tgfβ signaling is critical for maintenance of the tendon cell fate.Semantic proximity Read ↗

Widespread diversity in the transcriptomes of functionally divergent limb tendonsSemantic proximity Read ↗

The stiffness-sensitive transcriptome of human tendon stromal cellsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.