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Article

Tgfβ signaling is critical for maintenance of the tendon cell fate.

eLife - 21 Jan 2020

Tan Guak-Kim, Pryce Brian A, Stabio Anna, Brigande John V, Wang ChaoJie, Xia Zheng, Tufa Sara F, Keene Douglas R, Schweitzer Ronen

Abstract excerpt

Studies of cell fate focus on specification, but little is known about maintenance of the differentiated state. In this study, we find that the mouse tendon cell fate requires continuous maintenance in vivo and identify an essential role for TGFβ signaling in maintenance of the tendon cell fate. To examine the role of TGFβ signaling in tenocyte function the TGFβ type II receptor (Tgfbr2) was targeted in the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 31961320
DOI: 10.7554/eLife.52695
PMCID: PMC7025861

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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