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Article

In vivo functional validation of the V402L voltage gated sodium channel mutation in the malaria vector An. gambiae.

Pest management science - 1 Mar 2022

Williams Jessica, Cowlishaw Ruth, Sanou Antoine, Ranson Hilary, Grigoraki Linda

Abstract excerpt

BACKGROUND: Pyrethroids are the most widely used insecticides for the control of malaria transmitting Anopheles gambiae mosquitoes and rapid increase in resistance to this insecticide class is of major concern. Pyrethroids target the Voltage Gated Sodium Channels (VGSCs), that have a key role in the normal function of the mosquitoes' nervous system. VGSC mutations L995F and L995S have long been associated with...

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Identifiers

PMID: 34821465
DOI: 10.1002/ps.6731

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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