Article
Discovery of Knock-Down Resistance in the Major African Malaria Vector Anopheles funestus.
Molecular ecology - 1 Nov 2024
Odero Joel O, Dennis Tristan P W, Polo Brian, Nwezeobi Joachim, Boddé Marilou, Nagi Sanjay C, Hernandez-Koutoucheva Anastasia, Nambunga Ismail H, Bwanary Hamis, Mkandawile Gustav, Govella Nicodem J, Kaindoa Emmanuel W, Ferguson Heather M, Ochomo Eric, Clarkson Chris S, Miles Alistair, Lawniczak Mara K N, Weetman David, Baldini Francesco, Okumu Fredros O
Abstract excerpt
A major insecticide resistance mechanism in insect pests is knock-down resistance (kdr) caused by mutations in the voltage-gated sodium channel (Vgsc) gene. Despite being common in most malaria Anopheles vector species, kdr mutations have never been observed in Anopheles funestus, the principal malaria vector in Eastern and Southern Africa, with resistance mainly being conferred by detoxification enzymes. In a...
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