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Article

A protocol for the induction of experimental necrotizing enterocolitis in neonatal mice

11 Nov 2021

Abstract excerpt

Recapitulating human NEC using animal models has been insightful in dissecting the signaling pathways, immune-mediated mechanisms, genetic signatures, and the intestinal architecture of NEC. This protocol describes an in vivo murine NEC model, using hypoxia and formula containing lipopolysaccharide and enteric bacteria derived from an infant with NEC. With this mouse model, we aim to further dissect NEC...

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PMID: 34816129
DOI: 10.1016/j.xpro.2021.100951

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