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Article

A Pattern-based Pathology Approach to Very Early-onset Inflammatory Bowel Disease: Thinking Beyond Crohn Disease and Ulcerative Colitis.

Advances in anatomic pathology - 1 Jan 2022

Wilkins Benjamin J, Kelsen Judith R, Conrad Maire A

Abstract excerpt

Very early-onset inflammatory bowel disease (VEO-IBD), IBD diagnosed in children younger than 6 years old, is phenotypically and genetically distinct from older onset IBD. Monogenic and digenic causative defects, particularly in primary immunodeficiency and intestinal epithelial barrier genes, have been identified in a subset of patients with VEO-IBD allowing for targeted therapies and improved outcomes. However,...

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PMID: 34813528
DOI: 10.1097/PAP.0000000000000327
PMCID: PMC8665089

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