Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The evolutionary conserved TLDc domain defines a new class of (H+)V-ATPase interacting proteins.

Scientific reports - 22 Nov 2021

Eaton A F, Brown D, Merkulova M

Abstract excerpt

We recently found that nuclear receptor coactivator 7 (Ncoa7) and Oxr1 interact with the proton-pumping V-ATPase. Ncoa7 and Oxr1 belong to a group of proteins playing a role in the oxidative stress response, that contain the conserved "TLDc" domain. Here we asked if the three other proteins in this family, i.e., Tbc1d24, Tldc1 and Tldc2 also interact with the V-ATPase and if the TLDc domains are involved in all...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adenosine Triphosphatases
Share to GTPase-Activating Proteins
Share to Ions

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Mitochondrial Proteins

Share to Protein Domains

Share to RNA, Small Interfering

Share to Thermodynamics

Share to Vacuolar Proton-Translocating ATPases

Source

Open in PubMed Open full text

Identifiers

PMID: 34811399
DOI: 10.1038/s41598-021-01809-y
PMCID: PMC8608904

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The evolutionary conserved TLDc domain defines a new class of (H+)V-ATPase interacting proteins.PMID 34811399Read ↗

Crystal structure of the TLDc domain of human NCOA7-AS.Semantic proximity Read ↗

A human gene, ATP6E1, encoding a testis-specific isoform of H(+)-ATPase subunit E.Semantic proximity Read ↗

Interaction of yeast V-ATPase with TLDc protein Rtc5pSemantic proximity Read ↗

RPAP3 C-Terminal Domain: A Conserved Domain for the Assembly of R2TP Co-Chaperone ComplexesSemantic proximity Read ↗

RILP regulates vacuolar ATPase through interaction with the V1G1 subunitSemantic proximity Read ↗

Targeted deletion of the Ncoa7 gene results in incomplete distal renal tubular acidosis in mice.Semantic proximity Read ↗

Structural basis for ovarian tumor domain-containing protein 1 (OTU1) binding to p97/valosin-containing protein (VCP).Semantic proximity Read ↗

FXYD7, mapping of functional sites involved in endoplasmic reticulum export, association with and regulation of Na,K-ATPase.Semantic proximity Read ↗

A special member of the rice SRO family, OsSRO1c, mediates responses to multiple abiotic stresses through interaction with various transcription factors.Semantic proximity Read ↗

Two classes of proteins dependent on either the presence or absence of thyroid hormone for interaction with the thyroid hormone receptor.Semantic proximity Read ↗

AAA ATPases regulate membrane association of yeast oxysterol binding proteins and sterol metabolism.Semantic proximity Read ↗

A new member of the family of di-iron carboxylate proteins. Coq7 (clk-1), a membrane-bound hydroxylase involved in ubiquinone biosynthesis.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.