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Article

Methodology for clinical genotyping of CYP2D6 and CYP2C19.

Translational psychiatry - 22 Nov 2021

Carvalho Henriques Beatriz, Buchner Avery, Hu Xiuying, Wang Yabing, Yavorskyy Vasyl, Wallace Keanna, Dong Rachael, Martens Kristina, Carr Michael S, Behroozi Asl Bahareh, Hague Joshua, Sivapalan Sudhakar, Maier Wolfgang, Dernovsek Mojca Z, Henigsberg Neven, Hauser Joanna, Souery Daniel, Cattaneo Annamaria, Mors Ole, Rietschel Marcella, Pfeffer Gerald, Hume Stacey, Aitchison Katherine J

Abstract excerpt

Many antidepressants, atomoxetine, and several antipsychotics are metabolized by the cytochrome P450 enzymes CYP2D6 and CYP2C19, and guidelines for prescribers based on genetic variants exist. Although some laboratories offer such testing, there is no consensus regarding validated methodology for clinical genotyping of CYP2D6 and CYP2C19. The aim of this paper was to cross-validate multiple technologies for...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 34811360
DOI: 10.1038/s41398-021-01717-9
PMCID: PMC8608805

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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