Article
Zileuton Alleviates Radiation-Induced Cutaneous Ulcers via Inhibition of Senescence-Associated Secretory Phenotype in Rodents.
International journal of molecular sciences - 29 Jul 2022
Park Mineon, Na Jiyoung, Kwak Seo Young, Park Sunhoo, Kim Hyewon, Lee Sun-Joo, Jang Won-Suk, Lee Seung Bum, Jang Won Il, Jang Hyosun, Shim Sehwan
Abstract excerpt
Radiation-induced cutaneous ulcers are a challenging medical problem for patients receiving radiation therapy. The inhibition of cell senescence has been suggested as a prospective strategy to prevent radiation ulcers. However, there is no effective treatment for senescent cells in radiation ulcers. In this study, we investigated whether zileuton alleviated radiation-induced cutaneous ulcer by focusing on cell...
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