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Article

Phosphorylation of Lamin A/C at serine 22 modulates Nav 1.5 function.

Physiological reports - 1 Nov 2021

Olaopa Michael A, Ai Tomohiko, Chao Bo, Xiao Xiangshu, Vatta Matteo, Habecker Beth A

Abstract excerpt

Variants in the LMNA gene, which encodes for Lamin A/C, are associated with cardiac conduction disease (CCD). We previously reported that Lamin A/C variants p.R545H and p.A287Lfs*193, which were identified in CCD patients, decreased peak INa in HEK-293 cells expressing Nav 1.5. Decreased peak INa in the cardiac conduction system could account for patients' atrioventricular block. We found that serine 22 (Ser 22)...

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Identifiers

PMID: 34806324
DOI: 10.14814/phy2.15121
PMCID: PMC8606869

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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